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KMID : 0352419950140040330
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Keimyung Medical Journal
1995 Volume.14 No. 4 p.330 ~ p.339
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Effect of Common Bile Duct Ligation on Liver and Serum Glyoxalase-I Activies in Ethanol Intoxicated Rats
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Abstract
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The activities of the rat liver and serum glyoxalase-I(GLO-I) were studied in cholestasis induced by common bile duct(CBD) ligation after chronic ethanol intoxication, and in cholestasis before acute ethanol intoxication to establish the biochemical background of alcohol hazards in hepatobiliary disease.
GLO-I activities in the rat´s liver and serum showed less increases when CBD was ligated after chronic ethanol intoxication than that in the CBD ligation alone.
GLO-I activities in the rat´s liver and serum showed no more increases when acute ethanol intoxication was induced after CBD ligation than that in the CBD ligation alone.
On the other hand, when CBD was ligated after chronic ethanol intoxication, the value of Vmax of the liver GLO-I decreased significantly than that in the CBD was ligated alone. However, the values of Km of the liver GLO-I did not changes in the all experimental groups.
Viewed from above results, when chronic ethanol intoxication is combined with cholestasis, GLO-I in the liver seems to be decrease its activity than that in cholestasis, and the cause of the decrease is thought to be decreased biosynthesis.
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